Expression of transglutaminase 2 in human gut epithelial cells: Implications for coeliac disease
Background Formation of complexes between transglutaminase 2 (TG2) and gluten can mechanistically explain why TG2 serves both as B-cell autoantigen and as an enzyme that creates deamidated gluten epitopes in coeliac disease (CeD).A model has been proposed where TG2 released from shed epithelial cells encounters high concentrations of dietary gluten